E-ROSETTE INHIBITING SUBSTANCE IN HODGKINS-DISEASE SPLEEN EXTRACTS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 29  (3) , 369-375
Abstract
Patients with Hodgkin''s disease often manifest impairment of cell-mediated immune responses in in vivo and in vitro tests, and a markedly decreased percentage of E [erythrocyte] rosette-forming (T [thymus-derived]) lymphocytes in the peripheral blood. This report described the inhibition of E-rosette formation by normal peripheral blood lymphocytes after incubation with extracts prepared from the spleens of patients with Hodgkin''s disease. Such extracts also depressed E-rosette formation by the peripheral blood lymphocytes of patients with Hodgkin''s disease after those cells were restored to normal function by prior incubation in fetal calf serum. Similarly prepared extracts from the spleens of normal donors had no immunodepressive effect. The E-rosette inhibitory substance in the Hodgkin''s disease spleen extracts was a complex containing .beta.-lipoprotein, C-reactive protein and C1q [q subcomponent of the 1st complement component].