Biopharmaceutical aspects of FK-506.
- 1 October 1987
- journal article
- Vol. 19, 30-5
Abstract
FK is a potent immunosuppressive agent. FK can be analyzed in biologic fluids by EIA. The oral absorption of FK is rapid but variable in dogs. After intramuscular administration, FK is slowly and continuously absorbed. FK is primarily eliminated by metabolism. Less than 1% of the administered dose is excreted in the bile or the urine. After chronic intramuscular administration FK inhibits drug metabolism. Monitoring of FK levels in plasma is essential for the proper interpretation of efficacy and toxicity studies.This publication has 8 references indexed in Scilit:
- Role of bile and bile salts on cyclosporine absorption in dogs.1987
- THE EFFECTS OF CYCLOSPORINE-A (CSA) ON HEPATIC-MICROSOMAL DRUG-METABOLISM IN THE RAT1986
- Influence of Prednisolone on Antipyrine and Chloramphenicol Disposition in RabbitsPharmacology, 1984
- Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.1969
- The Carbon Monoxide-binding Pigment of Liver MicrosomesJournal of Biological Chemistry, 1964
- Hepatic Triphosphopyridine Nucleotide-Cytochrome c Reductase: Isolation, Characterization, and Kinetic StudiesJournal of Biological Chemistry, 1962
- The colorimetric estimation of formaldehyde by means of the Hantzsch reactionBiochemical Journal, 1953
- DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTIONJournal of Biological Chemistry, 1949