Chronic Rubella Virus Infection in the Ferret (Mustela putorius fero) Puppy

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Abstract
Newborn ferrets inoculated by different routes with rubella virus showed widespread and chronic infection for up to 3 months. CF [complement fixing] and neutralizing antibodies in infected animals persisted for a year post-infection. Puppies inoculated by the IC [intracranial] route had higher virus titer, longer chronic infection, higher rubella antibody titers, and some showed eye defects. The similarities between ferret puppy infection and human congenital rubella were discussed.

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