Structural Differences between Two Types of "Heavy Chain" Disease Proteins and Myeloma Globulins of Corresponding Types

31 July 1964

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 145 (3631) , 499-500
https://doi.org/10.1126/science.145.3631.499

Abstract

Structural differences between two antigenic types (designated C and Z) of γ-globulins, both of low molecular weight, produced in " Heavy chain" disease are revealed by their relative susceptibilities to enzymatic degradation by papain and the nature of the cleavage products. Corresponding structural differences exist between the respective type C and type Z myeloma γ²-globulins. These structural differences are tentatively assigned to the H-chains, and more specifically to the portion of the H-chain contained in the fast-moving (F) fragment of papain-treated γ²-globulins.

Keywords

This publication has 4 references indexed in Scilit:

Clinical and immunochemical studies of four cases of heavy (Hγ2) chain disease
The American Journal of Medicine, 1964
Heavy chain disease—A new disorder of serum γ-globulins
The American Journal of Medicine, 1964
PLASMA CELL MYELOMA
Medicine, 1963
The hydrolysis of rabbit γ-globulin and antibodies with crystalline papain
Biochemical Journal, 1959