LEUCINE‐ENKEPHALIN AND METHIONINE‐ENKEPHALIN PRODUCE OPPOSING EFFECTS ON PLASMA CORTICOSTERONE LEVELS IN ETHER‐STRESSED MICE

Open Access
Publisher Website
Google Scholar
Abstract
The inhibitory effects of intracerebroventricular administration of saline on the plasma corticosterone response to ether stress in mice was reduced by Met-enkephalin and enhanced by Leu-enkephalin. When administered simultaneously the effects of the two peptides opposed each other. Met and Leu-enkephalin may subserve different physiological functions in the response of the hypothalamus-pituitary-adrenal system to stress.