Human influenza virus recognition of sialyloligosaccharides
- 5 June 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 366 (1) , 57-60
- https://doi.org/10.1016/0014-5793(95)00488-u
Abstract
Sialic acids are essential components of cell‐surface receptors utilized by influenza viruses. To evaluate the recognition of asialic sugar parts of the receptor, three representative strains of human influenza A and B viruses were tested for their binding of a panel of sialyloligosaccharides. The highest affinity binding carbohydrate determinants recognized by the viruses in a context of different core structures were Neu5Acα2‐3Gal for the type B virus, Neu5Acα2‐6Gal for the H3 subtype virus, and Neu5Acα2‐6Ga/β1‐4GlcNAc for the H1 subtype virus. Penultimate to these determinants parts of sialyloligosaccharides studied either contributed less significantly to the binding affinity, or interfered with the binding.Keywords
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