Hydrolytic Behaviors of Trichloroethyl Phosphate in Rat Gastro-intestinal Tract

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Abstract
Hydrolysis of trichloroethyl phosphate, a model compound of phosphate esters, was examined in vitro using mucosal fluid of intestine and mucosal homogenate of the gastrointestinal tract of rats. Hydrolytic activity in mucosal fluid varied depedning on pH and prewashing. Hydrolytic activity in the mucosa decreased in the order of duodenum, jejunum and ileum. Some hydrolysis took place by mucosal homogenate of stomach at pH 7.4 whereas little hydrolysis was observed at pH 1.2. The ester is expected to be hydrolyzed in the mucosal fluid in intestine before absorption or be hydrolyzed in the mucosa after it is taken up intact.