Altered responsiveness to cocaine in rats exposed to methylphenidate during development
- 3 December 2001
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 5 (1) , 13-14
- https://doi.org/10.1038/nn777
Abstract
Evidence in laboratory animals indicates that exposure to stimulants produces sensitization to their rewarding effects1, a process that in humans would be expected to increase the risk of substance abuse. However, therapeutic administration of stimulants such as methylphenidate (MPH) in children with attention deficit hyperactivity disorder reportedly reduces the risk of substance abuse2. Here we show in rats that exposure to MPH during pre-adolescence causes behavioral and neurobiological adaptations that endure into adulthood, and that are consistent with increased sensitivity to the aversive effects of cocaine.Keywords
This publication has 13 references indexed in Scilit:
- Enhanced Reactivity and Vulnerability to Cocaine Following Methylphenidate Treatment in Adolescent RatsNeuropsychopharmacology, 2001
- Altered Responsiveness to Cocaine and Increased Immobility in the Forced Swim Test Associated with Elevated cAMP Response Element-Binding Protein Expression in Nucleus AccumbensJournal of Neuroscience, 2001
- Molecular basis of long-term plasticity underlying addictionNature Reviews Neuroscience, 2001
- The psychology and neurobiology of addiction: an incentive–sensitization viewAddiction, 2000
- Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaineNature, 1999
- Pharmacotherapy of Attention-deficit/Hyperactivity Disorder Reduces Risk for Substance Use DisorderPediatrics, 1999
- CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular SignalsAnnual Review of Biochemistry, 1999
- Evidence that the aversive effects of opioid antagonists and ?-agonists are centrally mediatedPsychopharmacology, 1989
- Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.Proceedings of the National Academy of Sciences, 1988
- Enduring Changes in Dopamine Receptor Cells of Pups from Drug Administration to Pregnant and Nursing RatsScience, 1979