OVULATION INDUCED BY SYNTHETIC LUTEINIZING HORMONE RELEASING FACTOR IN ANDROGEN-STERILIZED FEMALE RATS

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Abstract
It is well known that administration of a single injection of testosterone propionate to newborn female rats results in permanent anovulatory sterility. After puberty these animals show permanent vaginal cornification and their ovaries contain follicles but no corpora lutea (Barraclough, 1961). One of the most important lesions in these rats seems to be a blockade of the pre-ovulatory discharge of luteinizing hormone releasing factor (LH-RF) from the median eminence. Porcine LH-RF has been shown to be a decapeptide, pyro Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly(NH2), and when this polypeptide was synthesized it was found to have follicle-stimulating hormone releasing factor activity as well (Matsuo, Arimura, Nair & Schally, 1971; Matsuo, Baba, Nair, Arimura & Schally, 1971). In the present experiments we posed the question of whether a subcutaneous injection of synthetic LH-RF could induce ovulation in androgen-sterilized female rats, and if so, whether this would be a dose-dependent effect. Albino rats of the Sprague—Dawley

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