AQUEOUS PENICILLIN THERAPY FOR PNEUMOCOCCIC PNEUMONIA

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Abstract
The custom of injecting aqueous solution of penicillin intramuscularly or intravenously, or of giving it orally, at short intervals of three or four hours is based on the fact that the amount of penicillin in the blood rises and falls rapidly after its administration. It is believed that closely spaced dosage is necessary to maintain a constant bacteriostatic or bactericidal amount of penicillin in the blood to control infection. To avoid the need for rapidly repeated injections, which cause discomfort, disturb sleep and burden the nursing service, methods of injecting penicillin in various slowly absorbed matrixes were developed with the view to providing a continuous slow release of penicillin into the blood and the maintenance of a constant large amount therein. Unfortunately, injections of this kind often cause pain, unpleasant reactions and at times sterile abscesses and are costly. It is questionable whether the amount of penicillin in the blood

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