Intrarenal role of renin-angiotensin system in the regulation of renal hemodynamics

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Abstract
A reduction of renal arterial pressure in mongrel dogs to 70 mmHg caused marked increases in plasma renin activity and plasma levels of angiotensin I (AI) and angiotensin II (AII). Production of renin and AI but not AII in the kidney was seen. A reduction of renal arterial pressure caused a redistribution of blood flow from the outer to inner cortex. An arterial infusion of AII (200 ng/min), did not affect the intrarenal distribution of the blood flow. An intrarenal infusion of AII restored the normal pattern of the distribution of intrarenal blood flow altered by the pressure reduction. Apparently the renin-angiotensin system is not involved in the control of renal hemodynamics through the intrarenal formation of ALL and that the intrarenal hemodynamic changes caused by pressure reduction is due to the intrinsic difference in myogenic force in different cortical zones.