Cushing's syndrome due to unilateral nodular adrenal hyperplasia: a new pathophysiological entity?
- 1 April 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 93 (4) , 495-504
- https://doi.org/10.1530/acta.0.0930495
Abstract
A case is presented of a 43-yr-old Caucasian female with Cushing''s syndrome, malignant hypertension and renal insufficiency. Plasma cortisol values were elevated (19.5 .mu.g/100 ml at 0800 h and 18.5 .mu.g/100 ml at 2200 h) with loss of diurnal variation and failure of suppression with low- and high-dose dexamethasone. 17-Ketogenic steroid excretion remained unchanged after metyrapone administration. Adrenal vein plasma cortisol values showed a prominent left-sided gradient. Gross, histologic and EM examination of the left adrenal gland revealed changes of nodular adrenal hyperplasia. The presence of a suppressed right adrenal gland was confirmed post-operatively by a 5-day ACTH infusion. This case may represent a previously unreported variant of Cushing''s syndrome due to unilateral nodular adrenal hyperplasia.This publication has 9 references indexed in Scilit:
- Primary Adrenocortical Nodular Dysplasia: A Rare Cause of Cushing's Syndrome1Journal of Clinical Endocrinology & Metabolism, 1967
- Failure of dexamethasone suppression in adrenal hyperplasiaArchives of internal medicine (1960), 1966
- Cushing's syndrome with nodular adrenalhyperplasia in infancyThe Journal of Pediatrics, 1966
- Pituitary-Adrenal Functional Abnormalities in Corticogenic Adrenal AtrophyJournal of Clinical Endocrinology & Metabolism, 1965
- Unusual Case of Adrenocortical HyperfunctionJournal of Clinical Endocrinology & Metabolism, 1965
- Cushing's Syndrome: Nodular Cortical Hyperplasia of Adrenal Glands with Clinical and Pathological Features Suggesting Adrenocortical TumorJournal of Clinical Endocrinology & Metabolism, 1964
- Failure of Dexamethasone Suppression Test To Indicate Bilateral Adrenocortical Hyperplasia in Cushing's SyndromeJournal of Clinical Endocrinology & Metabolism, 1963
- TESTS OF PITUITARY-ADRENAL SUPPRESSIBILITY IN THE DIAGNOSIS OF CUSHING'S SYNDROME*Journal of Clinical Endocrinology & Metabolism, 1960
- CUSHING'S SYNDROME WITH MULTINODULAR ADRENAL GLANDS*Journal of Clinical Endocrinology & Metabolism, 1960