Electrochemical method for measuring C-reactive protein using crown ether-phosphate ester ionophores
- 1 November 1989
- journal article
- research article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 61 (21) , 2362-2365
- https://doi.org/10.1021/ac00196a009
Abstract
A new electrochemical method for measurement of C-reactive protein (CRP) is presented. We have synthesized new crown ether-phosphate ester ionophores having high affinity for CRP. A study using proton nuclear magnetic resonance shows CRP binding to the ionophores in stoichiometric amounts. The incorporation of these crown ether-phosphate ester ionophores into poly(vinyl chloride) membrane electrodes yields a CRP-sensitive electrode with sensitivity in the microgram per milliliter range. The ionophore synthesis and preliminary electrode characteristics are described.This publication has 6 references indexed in Scilit:
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