COMPARISON OF BIOAVAILABILITY AND PHARMACOKINETICS OF CIMETIDINE IN SUBJECTS WITH NORMAL AND IMPAIRED RENAL-FUNCTION

  • 1 January 1983
    • journal article
    • research article
    • Vol. 2  (2) , 157-162
Abstract
The bioavailability and pharmocokinetics of cimetidine [used in the treatment of peptic ulcer disease] were studied following single oral and i.v. doses in subjects with severely impaired renal function (SIRF) and normal renal function (NRF). Subjects [8] with NRF and 5 patients with SIRF participated. Multiple blood samples were obtained up to 1440 min following both doses. Urine was also collected for 24 h after each dose. The bioavailability of cimetidine was not significantly different between the 2 groups (78 .+-. 15% in patients with SIRF and 62 .+-. 17% in the NRF subjects). In subjects with NRF, a mean of 50.4% of the i.v. dose was excreted renally as unchanged drug and the mean serum half-life (t1/2) was 2.00 h. The mean total body and renal clearances were 710.0 and 370.7 ml/min, respectively. In the SIRF group, a mean of 1.7% of the i.v. dose was excreted renally unchanged, and the mean t1/2 was 12.71 h. The total body and renal clearances were 147.1 and 2.5 ml/min, respectively. Nonrenal clearance was 62% lower in the subjects with SIRF than in the NRF subjects. There is no significant difference in bioavailability of cimetidine between the patients with NRF and SIRF. The significantly lower nonrenal clearance of the patients with SIRF suggests that cimetidine metabolism may be impaired in uremic patients.

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