Inhibition of Infectivity and Replication of HIV-2 and SIV in Helper T-Cells by 2′,3′-Dideoxynucleosides In Vitro
- 1 January 1988
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 4 (2) , 107-113
- https://doi.org/10.1089/aid.1988.4.107
Abstract
We have previously shown that 2′,3′-dideoxynucleosides and their derivatives are potent inhibitors of the infectivity and cytopathic effect mediated by human immunodeficiency virus type-1 (HIV-1), the causative agent of acquired immunodeficiency syndrome (AIDS). Recently a new group of retroviruses has been found in individuals originating from the western part of Africa. One member of this group is human immunodeficiency virus type-2 (HIV-2), previously designated lymphadenopathy-associated virus type-2 (LAV-2), found in patients with an AIDS-like illness. In this report, we show that 2′,3′-dideoxynucleosides including 3′-azido-2′,3′-dideoxythymidine (AZT) can significantly inhibit the infectivity and/or cytopathic effect of these retroviruses in vitro. Current data provide a rationale for considering 2′,3′-dideoxynucleosides and their derivatives as experimental antiviral agents in individuals with illnesses caused by these new retroviruses.This publication has 22 references indexed in Scilit:
- Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivityBiochemical Pharmacology, 1987
- Broad spectrum antiretroviral activity of 2',3'-dideoxynucleosides.Proceedings of the National Academy of Sciences, 1987
- Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro.Proceedings of the National Academy of Sciences, 1987
- Strategies for antiviral therapy in AIDSNature, 1987
- Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.Proceedings of the National Academy of Sciences, 1986
- Initial studies on the cellular pharmacology of 2′,3′-dideoxycytidine, an inhibitor of HTLV-III infectivityBiochemical Pharmacology, 1986
- Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.Proceedings of the National Academy of Sciences, 1986
- 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.Proceedings of the National Academy of Sciences, 1985
- Human T-lymphotropic retrovirusesNature, 1985
- Sequence homology between retroviral reverse transcriptase and putative polymerases of hepatitis B virus and cauliflower mosaic virusNature, 1983