Malaria Vaccines: Back to the Future?

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Abstract
The malaria parasite kills several million people each year, many of them young children in sub-Saharan Africa. A forty-year effort to develop either a subunit or attenuated whole-organism vaccine has met with little success. However, as Andy Waters and colleagues discuss in their Perspective, a new study in mice using genetically attenuated sporozoites of a rodent malaria parasite has yielded a promising protective response in vaccinated animals. The Perspective authors discuss the possibility of developing a human malaria vaccine based on this strategy.