Antigen-induced decrease of salicylic acid absorption from the small intestine in actively immunized rats.

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Abstract
Rats were i.p. immunized with bovine .gamma.-globulin (BGG) emulsified in incomplete Freund''s adjuvant. Intestinal absorption of salicylic acid from the rat small intestine was examined by in situ recirculation technique. The disappearance of salicylic acid from the luminal solution was significantly decreased in rats challenged i.v. with BGG compared to saline as control. A significant decrease in absorption of salicylic acid was noted in rats immunized 2 and 3 times, but not in rats immunized only once. The effect was maintained for at least 5 wk after the 3rd immunization, whereas it disappeared within 10 wk. In normal rats, the decreased absorption of salicylic acid by i.v. challenge with BGG was hardly observed at all. The intestinal absorption of salicylic acid may be affected by systemic anaphylaxis in actively immunized rats.