EFFECT OF ELECTROSHOCK AND ANTIDEPRESSANT DRUGS ON CEREBROVASCULAR PERMEABILITY TO COCAINE IN THE RAT
- 1 April 1966
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Nervous & Mental Disease
- Vol. 142 (4) , 376-380
- https://doi.org/10.1097/00005053-196604000-00008
Abstract
The data presented in this work demonstrate that treatment of the rat with the antidepressant drugs, imipramine, amitriptyline, and nortriptyline, results in permeability changes in the central nervous system on approximately the same order of magnitude as such changes induced by electroshock. In contrast to the effect of the antidepressant drugs, treatment with chloropromazine does not significantly alter the blood-brain barrier permeability to cocaine in the rat. It is suggested that these results lend support to the concept that the therapeutic effects of electroshock may be related in some way to its action on cerebrovascular permeability.This publication has 2 references indexed in Scilit:
- EFFECTS OF ELECTROSHOCK AND TRYPAN RED ON THE BLOOD-BRAIN BARRIER AND RESPONSE RETENTION IN THE RATJournal of Nervous & Mental Disease, 1965
- THE ROLE OF FEAR IN ELECTRO CONVULSIVE TREATMENTJournal of Nervous & Mental Disease, 1963