IMAGING OF INFLAMMATION WITH IN-111 TROPOLONATE LABELED LEUKOCYTES

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  • 1 January 1983
    • journal article
    • research article
    • Vol. 24  (1) , 39-44
Abstract
111In tropolonate is a new cell-labeling agent. It has the interesting property of labeling cells in plasma with high efficiency, and may therefore promote an improvement in viability of labeled cells. 111In tropolonate was used as a leukocyte label for abscess imaging. Pure populations of separated granulocytes, as well as crude leukocyte preparations, were labeled. Of 101 studies performed, 51 were positive (no false-positives) and 50 negatives, of which only 2 were false-negatives. Localization in sites of inflammation was prominent and rapid. Of 36 positive studies, 27 were already positive at 40 min following injection and an additional 9 at 3 h. Of the other 15 positive studies, 11 were scanned for the 1st time at 3 h, when they were positive. Granulocytes labeled with this agent in plasma showed minimal sequestration in lungs and liver, interpreted as indicating improved viability in comparison with cells displaying prolonged lung sequestration.