Comparative Studies on Cardiotoxicity of Some Anthracycline Antitumor Antibiotics
- 1 January 1980
- book chapter
- Published by Springer Nature
- Vol. 4, 399-401
- https://doi.org/10.1007/978-3-642-67729-8_89
Abstract
Isolated atria of guinea-pigs showed negative inotropic and negative chronotropic responses after violamycin B I (V), carminomycin (C) and daunomycin (D), respectively. The mean effective concentrations in reducing amplitude (IC50) were 5.9 × 10–4 mol × 1–1 for V and 1.3 × 10–4 mol × 1–1 for C and D. In rabbits, intravenous injections of different doses of the antibiotics twice weekly for one month produced histopathological alterations in the myocardial tissue, which were smaller after D than after C or V.Keywords
This publication has 1 reference indexed in Scilit:
- Violamycin, a new red-pigment antibioticJournal of Basic Microbiology, 1974