EXPERIMENTAL THYROID HYPERPLASIA

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Abstract
At the present time endemic goiter is commonly placed in the category of a deficiency disorder, and attention is being focused on iodine as the lacking element. This is a natural tendency because of its apparent therapeutic value. Hellwig1 opposed this point of view and stated that a positive factor and not a deficiency of iodine is the essential cause. He believes that an increased intake of calcium chloride represents a positive agent, and if combined with a deficiency of iodine hyperplasia of the thyroid will result. My purpose in this paper is to report an experimental study on thyroid hyperplasia produced in a relatively nonendemic region based on the theory that calcium chloride represents a positive factor. REVIEW OF THE LITERATURE Knappenburg,2 in 1919, reported negative results in a series of rats fed on water containing but a small amount of iodine. His experiments were conducted in

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