Studies on the Hydrolysis of Biocompatible Acrylic Polymers Having Aspirin-Moieties
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in Biomaterials, Medical Devices, and Artificial Organs
- Vol. 11 (2-3) , 211-219
- https://doi.org/10.3109/10731198309118807
Abstract
Both the homogeneous and heterogeneous hydrolysis of five new acrylic polymers having aspirin-moieties, i.e. polymers of β-(acetylsalicylyloxy)ethyl methacrylate, β-(acetylsalicylyl-oxy)propyl methacrylate, β-(acetylsalicylyloxy)ethyl acrylate, β-hydroxy-γ-(acetylsalicylyloxy) propyl methacrylate, β-hydroxy-γ-(acetylsalicylyloxy) propyl acrylate were investigated in acidic or alkaline medium at 30°C or 60°C, respectively. It was observed that the chief hydrolyzed product is always aspirin with minor amount of salicylic acid.This publication has 3 references indexed in Scilit:
- Kinetics of Hydrolysis of Acylals of Aspirin: Hydrolysis of (1′-Ethoxy)Ethyl 2-AcetoxybenzoateJournal of Pharmaceutical Sciences, 1974
- The swelling implantJournal of Biomedical Materials Research, 1971
- Direct Spectrophotometric Determination of Salicylic Acid, Acetylsalicylic Acid, Salicylamide, Caffeine, and Phenacetin in Tablets or PowdersJournal of Pharmaceutical Sciences, 1966