Combination of a new amide-precursor reagent and trimethylsilyl bromide deprotection for the Fmoc-based solid phase synthesis of human pancreastatin and one of its fragments (Fmoc = fluoren-9-ylmethoxycarbonyl)
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 24,p. 1588-1590
- https://doi.org/10.1039/c39880001588
Abstract
A 52- and a 29-residue peptide amide corresponding to human pancreastatin and one of its fragments were synthesized by the Fmoc-based solid phase techniques (Fmoc = fluoren-9-ylmethoxycarbonyl), and a new amide precursor reagent, 3-(α-Fmoc-amino-4-methoxybenzyl)-4-methoxyphenylpropionic acid, was employed in combination with thioanisole-mediated trimethylsilyl bromide deprotection; the synthetic peptides significantly inhibited protein output, but not juice flow or bicarbonate output from rat pancreas.Keywords
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