Distribution and Metabolism of Tryptamine in Rat Brain

Publisher Website
Google Scholar
Abstract
Following intraventricular injection in untreated rats, the only metabolites of tryptamine isolated were indoleacetic acid and indoleacetaldehyde; the indication is that the acid is formed from the aldehyde during the isolation procedure. Additional metabolites (N-methyltryptamine and N,N-dimethyltryptamine) were formed in small quantities if the animals had been pretreated with pargyline. N-acetyltryptamine was not found if acetate ions were excluded during the isolation of the amine fraction.More tryptamine remained in the hypothalamus than any other region at all times following injection, both in the presence and absence of pargyline. Incubation with slices indicated a temperature dependent active uptake process in all regions.The loss of injected tryptamine from all regions in the presence of pargyline, and from the hypothalamus, cerebellum, and 'rest' in the absence of pargyline followed a pattern of rapid initial loss and then slower decline. This pattern was neither linear nor exponential. All the data, however, indicate a rapid turnover of the injected amine.

This publication has 0 references indexed in Scilit: