Evidence for the long-term biological distribution of Technegas particles
- 1 July 1993
- journal article
- review article
- Published by Wolters Kluwer Health in Nuclear Medicine Communications
- Vol. 14 (1) , 559-561
- https://doi.org/10.1097/00006231-199307000-00007
Abstract
Technegas is a suspension of structured graphite ellipsoids, between 5 and 20 nm in aerodynamic diameter and labelled, in a carrier gas of argon, with 99Tcm. Its emergence and rapidly expanding clinical usage (105,000 studies, 22 countries), as a unique dry insoluble microaerosol for diagnostic lung imaging, has prompted a review of reports of experiments on lung clearance with other aerosols. No direct comparison exists although it is clear that experimental inhalation insults which deliver to the alveoli a mass of material orders of magnitude greater than Technegas are well tolerated by human volunteers.Keywords
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