Intracranial aneurysms and subarachnoid hemorrhage --- report on a randomized treatment study. IV-B. Regulated bed rest --- statistical evaluation.

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Abstract
Regulated bed rest was 1 of 4 treatment modalities evaluated in a randomized clinical trial conducted during 1963-1970 for patients with a ruptured intracranial aneurysm. A life table method of statistical analysis was used to determine cumulative mortality and rebleeding rate during a 5 yr follow-up period for 187 patients in this treatment program and for subgroups of this patient sample. Linear discriminant function analysis was used to develop equations of clinical variables to predict mortality and rebleeding during the 90 day period following the bleed. The clinical variables most indicative of mortality included a poor initial neurological and medical state and sex (male). Other variables somewhat indicative of high mortality but not reaching statistical significance included a short interval from last bleeding to treatment, high mean blood pressure and a large aneurysm. Aneurysm site, age, number of bleeds, pre-existing hypertension and evidence of vasospasm were not indicative of higher mortality. The clinical variables most related to rebleeding included a short interval from the last bleed to treatment and sex (male). Other variables less related to rebleeding but not reaching statistical significance included a high mean blood pressure and the numbers of bleeds in the medical history. Aneurysm site, initial neurological and medical state, age, aneurysm size, pre-existing hypertension and evidence of vasospasm did not appear to be related to rebleeding. The discriminant functions derived were used to reclassify the subjects into dead and alive, and rebleeding and no rebleeeding 90 days after initial hemorrhage. The misclassification percentages were substantial, making doubtful the prediction of mortality and rebleeding.