GENERATION AND DIELS–ALDER REACTION OF 1-SILOXY-3-ARYLISOBENZOFURANS FROM 3-ARYLPHTHALIDES
- 5 July 1984
- journal article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 13 (7) , 1263-1266
- https://doi.org/10.1246/cl.1984.1263
Abstract
1-t-Butyldimethylsiloxy-3-arylisobenzofurans, a new type of isobenzofurans, were generated from 3-arylphthalides by sequential treatment with LDA and TBDMSCl. The isobenzofurans, thus formed, were intercepted in situ by dimethyl fumarate to give stable Diels–Alder adducts in good yields. These adducts were converted into 4-aryl-1-naphthols by acid treatment. This new route for the preparation of naphthols was applied to the synthesis of natural arylnaphthalide lignan, diphyllin.Keywords
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