THE IMPORTANCE OF CATECHOLAMINE UPTAKE INHIBITION IN THE REVERSAL OF GUANETHIDINE BLOCKADE OF ADRENERGIC-NEURONS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 30  (1) , 3-14
Abstract
Adrenergic neuron blockade was induced by guanethidine in the pithed rat preparation. The pressor response to spinal electric stimulation was inhibited. The guanethidine blockade was reversed or prevented by tricyclic antidepressants and tripelennamine (an H1 antihistamine), tranylcypromine (a monoamine oxidase inhibitor) and viloxazine (a new antidepressant structurally unrelated to tricyclic antidepressants). Since these compounds all share neuronal uptake inhibitory activity, this property may be sufficient to reverse/prevent the adrenergic neuron blockade induced by guanethidine.

This publication has 1 reference indexed in Scilit: