Biaryl Synthesis via Direct Arylation: Establishment of an Efficient Catalyst for Intramolecular Processes
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- 10 July 2004
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (30) , 9186-9187
- https://doi.org/10.1021/ja049017y
Abstract
In this Communication, we describe direct arylation reactions with improved scope and catalyst activity for the intramolecular formation of biaryl compounds. This was achieved through the establishment of a highly active and robust catalyst system and the subsequent development of a novel phosphine ligand 27. The enhanced catalytic activity extends these transformations to include previously unreactive and poorly reactive substrates, and allows for very low catalyst loadings to be employed-as little as 0.1 mol %.Keywords
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