Neoplastic and Non-Neoplastic Renal Disease in Praomys (Mastomys) Natalensis

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Abstract
Five tumors of the kidney were observed in 188 of 195 untreated Mastomys necropsied: 2 clear-cell adenocarcinomas, 1 papillary cyst adenocarcinoma, 1 small cystic adenoma, and 1 hemangioma. All but 17 of the 188 animals from which histologic sections were available and suitable for diagnosis had some type of non-neoplastic renal disease. Approximately one Fourth of the Mastomys had hydronephrosis, suppurative pyelonephritis, or focal nephritic scars of the types observed in other rodents, but the predominant renal disease was glomerulonephritis. The lesions of glomerulonephritis were comparable to those of man except that, apart from the capillaries and efferent and afferent vessels of the glomerulus, the renal vascular system was unimpaired. Many renal changes in the Mastomys resembled those in the mice of the NZB/BI strain and its outcrosses.

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