Inhibition of Vagally Stimulated Gastric Acid by the Pyloric Antrum

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Abstract
It has been previously demonstrated that gastric acid production of antral and intestinal origin is inhibited by acidification of the antrum. In this experiment a vagally innervated gastric pouch (Hollander) and an excluded antral pouch were constructed in four animals, two of the antral pouches being vagally innervated and two denervated. The gastric pouches were stimulated to secrete in response to insulin hypoglycemia and the effect of acidification of the antrum tested. It was found that gastric secretion was reduced by acidification whether the antrum was denervated or not, the difference between the two being insignificant. It was concluded that the gastric acid produced in response to vagal stimulation is reduced by acidification of the antrum and that denervation of the antrum did not influence this result.

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