Cold resistance of kidney cells of mammalian hibernators: cation transport vs. respiration

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Abstract
Lowering of temperature causes a more profound depression of rate and extent of K uptake in leached slices of renal cortex of guinea pigs and rats than in those of hamsters, ground squirrels, and rabbits. A decrease in tissue K content below the depressed level caused by leaching occurs at 5 C in kidney slices of guinea pig with ouabain and in kidney slices of rats with anaerobic incubation, which may indicate a residual rate of transport in these species at low temperature. When slices of all species are incubated with ouabain or in Na-free media, a depression of O2 consumption is observed at all temperatures tested between 38 and 5 C. The molar K/O2 ratio is undiminished by lowering temperature in kidney slices of hamsters, ground squirrels, and rabbits. In kidney slices of guinea pigs the K/O2 ratio is drastically decreased at 5 C, and is somewhat diminished in kidney slices of rats. In nonhibernating rodents cation transport may be more sensitive to temperature than the supporting respiration.

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