PROLONGATION OF MURINE SKIN ALLOGRAFTS ACROSS A MAJOR HISTOCOMPATIBILITY LOCUS USING SUPERNATANTS FROM CON-A ACTIVATED SPLEEN-CELLS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 31  (7) , 196-198
Abstract
Supernatants from concanavalin [Con] A-activated mouse spleen cell cultures prolonged skin graft survival across the H-2 locus in the mouse. There existed in these supernatants non-specific factors synthesized by suppressor T [thymus-derived] cells which were activated by sub-optimal concentrations of Con A in vitro. The possible nature of these factors was discussed.