Methylmercury(II) sulfhydryl interactions. Potentiometric determination of the formation constants for complexation of methylmercury(II) by sulfhydryl containing amino acids and related molecules, including glutathione
- 1 July 1983
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 61 (7) , 1428-1434
- https://doi.org/10.1139/v83-250
Abstract
Formation constants for the interaction of methylmercury(II) with 2-mercaptoethanol, mercaptoacetic acid, O-methylmercaptoacetate, 2-mercaptosuccinic acid, L-Cys, D,L-penicillamine, N-acetyl-D,L-penicillamine, glutathione, thiocholine and 4-mercapto-N-methylpiperidine were determined by potentiometric titration. For the equilibrium MeHg+ + RS .dblarw. [McHgSR]1-n, log .beta. occurred in the range 14.60(1)-17.41(1), with the lowest value obtained for the cationic complex of thiocholine, .**GRAPHIC**. Acid Kd for the ligands were reported. Formation constants for the addition of 1 and 2 equivalents of MeHg(II) to L-Cys were determined, giving log K .apprx. 4.1 for the reaction .**GRAPHIC**. + MeHg+ .dblarw. .**GRAPHIC**. occurring at low pH, and log K 8.8 for the reaction MeHgSCH2CH(NH2)CO2- + MeHg+ .dblarw. .**GRAPHIC**. occurring at higher pH.This publication has 1 reference indexed in Scilit:
- An improved computer program for the computation of formation constants from potentiometric dataInorganica Chimica Acta, 1976