Hereditary abnormalities of the OKT4 human lymphocyte epitope in two families
- 1 January 1984
- journal article
- research article
- Published by Springer Nature in Journal of Clinical Immunology
- Vol. 4 (1) , 71-74
- https://doi.org/10.1007/bf00915290
Abstract
The lymphocytes of two unrelated black individuals exhibited no immunofluorescent staining by a monoclonal antibody, OKT4, that reacts with T helper/inducer cells, but the lymphocytes reacted normally with four other monoclonal antibodies that identify T helper cells. Four first-degree relatives of these individuals were available for study. They had a normal proportion of OKT4+ lymphocytes but these cells had approximately half the normal number of OKT4 sites. This abnormality appears to be inherited as an autosomal recessive state.Keywords
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