3-Hydroxyisoxazole-5-hydroxamic acid
- 1 July 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (7) , 965-967
- https://doi.org/10.1021/jm00217a023
Abstract
The synthesis of the title compound, 3-hydroxyisoxazole-5-hydroxamic acid (4b), by 2 procedures is described. The 1st, involving the treatment of dimethyl acetylenedicarboxylate with hydroxylamine, was previously reported to give the 3-hydroxyisoxazole-5-carboxylic acid (4a). In the 2nd, treatment of chlorofumaroyl dichloride with hydroxylamine also gave the intermediate chlorofumarodihydroxamic acid (6). Compound 6 had some activity against P388 lymphocytic mouse leukemia.This publication has 0 references indexed in Scilit: