A Methodology for Assessing Carcinogenic Hazards of Chemicals

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Abstract
Assessment of carcinogenic hazards of substances involves evalua tion and classification of qualitative and quantitative data, includ ing the attendant uncertainty,. Recently proposed EPA guidelines represent a significant step towards a uniform carcinogenic risk assessment procedure and its appropriate use. The Methodology for Assessing Carcinogenic Hazards of Chemicals proposed here shares common characteristics with the EPA guidelines but it also focuses on other aspects of carcinogen assessment, not addressed by the guidelines, such as: folding together quantitative and quali tative data into a combined hazard index; classification of limited, incomplete or flawed qualitative data; utilization of quantitative risk estimates based on weak qualitative evidence.