Hormone-Influenced Serum Protein (HIP): Anti-Protein System in the Chicken
Open Access
- 1 April 1971
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 106 (4) , 1104-1111
- https://doi.org/10.4049/jimmunol.106.4.1104
Abstract
A hormone-influenced serum protein (Hip) has been detected in some laying hens, and a “naturally” occurring anti-Hip antibody has been found in some hens lacking Hip. Hip has a molecular weight of about 150,000 and migrates as a β globulin in immunoelectrophoresis. Anti-Hip is an IgG antibody. Hip occurs with high frequency in certain families, indicating a possible genetic influence or expression. Treatment with progesterone induced synthesis of Hip in both females and males, but anti-Hip was produced only in females. Several factors that may be responsible for this “protein-anti protein” system are discussed.Keywords
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