INHIBITION OF THE R3327MAT-LU PROSTATIC TUMOR BY DIETHYLSTILBESTROL AND 1,2-BIS(3,5-DIOXOPIPERAZIN-1-YL)PROPANE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 42  (4) , 1390-1394
Abstract
The inhibitory effects of diethylstilbestrol on the growth of the androgen-independent, anaplastic Copenhagen rat prostatic tumor, R3327AT, which has a low metastatic potential, were previously described. A variant of the R3327AT tumor that metastasizes exclusively to the lungs was selected and designated the R3327MAT-Lu. In a dose-response protocol, diethylstilbestrol was inhibitory to the primary R3327MAT-Lu tumor, thereby also inhibiting the formation of lung metastases. Inhibition was also observed in this model tumor by the chemotherapeutic agent 1,2-bis(3,5-dioxopiperazin-1-yl)propane.

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