[Structure-activity relationships in the diuretic xipamide (4-chloro-5-sulfamoyl-2', 6' -salicyloxylidide)].

  • 1 February 1975
    • journal article
    • abstracts
    • Vol. 25  (2) , 240-4
Abstract
The synthesis of various derivatives of 4-chlorosalicylic acid substituted in position 5 is described. The evaluation of their diuretic potency on the rat showed 4-chloro-5-sulfamoyl-2,6-salicyloxylidide (BE 1293, xipamide, Aquaphor) as the most effective one. The normal urinary volume is increased tenfold by a oral dose of 100 mg/kg body weight. All changes in the molecular structure of xipamide, even acetylation, the introduction of a second sulfamoyl group or the exchange of the sulfonic group for the carbonyl group, lead to a decrease in activity.

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