Methacholine Inhalation Challenge after Rapid Saline Infusion in Healthy Subjects
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in Respiration
- Vol. 50 (1) , 18-22
- https://doi.org/10.1159/000194902
Abstract
Five healthy subjects were challenged with methacholine on 2 different days, 1 week apart, the second day after acute intravenous 30 ml/kg 0.9% saline infusion. After infusion, we observed a significant reduction in vital capacity (VC), maximal expiratory volume in 1 s (FEV1), provocation dose producing a 35% fall in SGaw (PD35SGaw) and in 25% of maximal expiratory flow (MEF25), and an increase in the slopes of log dose-response curves. Our results suggest an increased bronchial reactivity in acute minimal interstitial lung edema.This publication has 7 references indexed in Scilit:
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