Inability of men mutants of Escherichia coli to use trimethylamine-N-oxide as an electron acceptor
- 1 September 1984
- journal article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 24 (1) , 57-62
- https://doi.org/10.1016/0378-1097(84)90340-9
Abstract
Mutants of Escherichia coli blocked in the biosynthesis of menaquinone were unable to use trimethylamine-N-oxide as an electron acceptor in complex medium containing glucose. Trimethylamine-N-oxide reduction and the consequent in-crease in growth could be restored in a menC mutant by either o-succinylbenzoic acid (OSB) or 1,4-dihydroxy-2-naphthoic acid (DHNA). In the case of a menB mutant, growth could not be restored by OSB; but addition of DHNA resulted in the restoration of growth to the full extent. These results are consistent with the metabolic blocks in the respective men mutants.Keywords
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