Organization of restriction-modification systems
- 25 May 1991
- journal article
- review article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 19 (10) , 2539-2566
- https://doi.org/10.1093/nar/19.10.2539
Abstract
The genes for over 100 restriction-modification systems have now been cloned, and approximately one-half have been sequenced. Despite their similar function, they are exceedingly heterogeneous. The heterogeneity is evident at three levels: in the gene arrangements; in the enzyme compositions; and in the protein sequences. This paper summarizes the main features of the R-M systems that have been cloned.Keywords
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