DEMONSTRATIONS OF EXPERIMENTAL WORK IN THE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE

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Abstract
It is generally recognized that considerable light will be thrown on the histogenesis of cancer, especially that of internal organs, through the study of early cases, and through the study of inflammatory or other irritative processes that may produce excessive epithelial proliferation. Much that would increase the knowledge of carcinoma of the lung was hoped for after the influenza epidemic of 1919 and 1920. One is struck, however, by the fact that although innumerable pathologic reports have been published on influenza, only a few mention excessive regeneration of the epithelium of the lung that may possibly be interpreted as significant in the etiology of carcinoma. Askanazy,1 Glaus and Fritsche,2 Winternitz and others,3 Wolbach and Frothingham4 and Schmidtmann5 have described epithelial proliferation that appears to begin in the bronchus and may invade the alveoli and in some instances the peribronchiolar tissue. Most of the cases described

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