Acute hemorrhagic cystitis. Industrial exposure to the pesticide chlordimeform

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Abstract
An outbreak of hematuria occurred from May 20-May 23, 1975, among employees of a chemical packaging plant. Nine of 22 workers who packaged the insecticide chlordimeform in a separate shed became severely ill with abdominal pain, dysuria, urgency to void or hematuria. None of 18 persons who worked in other areas of the plant were affected. Four additional workers who had packaged the chemical during the previous year had a history of similar symptoms. Bladder biopsy specimens from 3 affected persons showed severe hemorrhagic cystitis; chlordimeform and 2-methyl-4-chloroaniline, a metabolite of chlordimeform, were present in urine specimens collected 3 days after exposure. The illness lasted from 1 wk to 2 mo.; the workers recovered completely. Chlordimeform that was injected s.c. into 3 cats produced similar, though less severe, changes in the bladders of 2 animals.

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