Dual Pathways of Complement Interaction with Guinea Pig Immunoglobulins

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Abstract
Further evidence is provided to document the availability of dual pathways for the interaction of C with guinea pig immunoglobulins. Preformed aggregates containing the γ1 molecules, bypass C1, C4 and C2 in their attack on C3. This reaction is rapid, and is inhibited by salicylaldoxime or dilution of the serum used as a source of C. Magnesium provides the essential divalent cation for this fixation process, which is more efficient at 37°C than at 4°C. Preformed aggregates containing γ2 antibodies fix C more slowly, a process which is not diminished as the serum C is diluted and is not inhibited by salicylaldoxime. Preformed complexes of these immunoglobulins also require magnesium for the C3 shunt pathway.

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