Enhancement of neuromuscular recovery after nerve repair in primates
- 30 June 1987
- journal article
- Published by SAGE Publications in Journal of Hand Surgery (European Volume)
- Vol. 12 (2) , 211-217
- https://doi.org/10.1016/0266-7681(87)90015-5
Abstract
This investigation describes the use of the calcium-activated protease inhibitor, leupeptin, as an adjunctive therapy to the microsurgical repair of median nerves in a primate model. Our results indicate that leupeptin facilitates morphological recovery in denervated thenar muscles and in distal sensory and mixed motor-sensory nerve trunks and functional recovery measured by motor nerve conduction velocity. Toxicological testing of leupeptin showed that, when administered at a dose of 12mg/kg, intramuscularly, once daily, haematological and clotting profiles were not adversely affected.Keywords
This publication has 0 references indexed in Scilit: