Can changes of ryanodine receptor expression affect cardiac contractility?

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Abstract
Yamamoto et al. [1] have shown in their recent article that the expression of cardiac ryanodine receptors is decreased in dogs subjected to heart failure induced by rapid-pacing. This agrees with previous work showing that in some models of failure down regulation of the RyR is observed [2,3]. As well as a decrease in the number of RyRs, it has also been suggested that there may be a decrease in the functional coupling between Ca entry into the cell and the opening of the RyR [4,5]. The purpose of this letter is to question the idea that changes in the expression or properties of the RyR are involved in changes of contractility observed in cardiac hypertrophy or failure. The argument below is based on both experimental and theoretical considerations [6]. We have examined the effects of manoeuvres which alter the open probability of the RyR. For example caffeine …

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