The Kinetics of Electrical Activity of Beta Cells in Response to a "Square Wave" Stimulation with Glucose or Glibenclamide
- 1 January 1976
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 8 (01) , 11-16
- https://doi.org/10.1055/s-0028-1093685
Abstract
The effect of a "square wave" stimulation with glucose or glibenclamide on the electrical activity of β-cells has been studied with microelectrode techniques in isolated perfused mouse islets. While glucose evoked a burst activity with periodic oscillations of the membrane potential between two levels, glibenclamide produced a constant depolarization with a continuous spike activity. In both cases the time course of activity was biphasic and resembled closely the corresponding patterns of insulin release. The effect of glibenclamide on the membrane was irreversible. The results provide further evidence for a direct correlation between insulin release and electrical activity. Further more, it is suggested that the membrane potential is, at least in part, involved in the mechanism of biphasic insulin release. 1 Supported by Deutsche Forschungsgemeinschaft, Bad Godesbcrg (SFB 38 ,,Mcmbranforschung").Keywords
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