Kinetic studies of lipoprotein metabolism in the metabolic syndrome including effects of nutritional interventions
- 1 February 2003
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Lipidology
- Vol. 14 (1) , 61-68
- https://doi.org/10.1097/00041433-200302000-00011
Abstract
Nutritional interventions may favourably regulate dyslipoproteinemia and, hence, decrease cardiovascular disease risk. Lipoprotein kinetic studies afford a powerful approach to understanding and defining the mechanisms by which such interventions modulate lipoprotein metabolism. Stable isotope tracers and compartment models are now commonly employed for such studies. We review the recent application of tracer methodologies to the study of dyslipoproteinemia in the metabolic syndrome. We also focus on the effects of nutritional intervention studies that have addressed the effects of weight loss, n-3 fatty acids, plant sterols and alcohol on very low density lipoprotein, LDL and HDL metabolism. The potential for statin treatment as an adjunct to dietary modification is also discussed. New tracer methodologies are discussed, specifically those referring to reverse cholesterol transport. The nutritional interventions discussed in this review are readily transferable into clinical preventive practice. The potential benefits to be gained by weight loss and fish oil supplementation in the metabolic syndrome extend beyond their specific and positive effects on lipoprotein metabolism. Furthermore, recent developments in tracer methodologies afford new tools for probing the in-vivo pathways of lipoprotein metabolism in future studies.Keywords
This publication has 51 references indexed in Scilit:
- Apolipoprotein B metabolism in humans: studies with stable isotope-labeled amino acid precursorsAtherosclerosis, 2002
- Lipoproteins, nutrition, and heart diseaseThe American Journal of Clinical Nutrition, 2002
- Prevalence of the Metabolic Syndrome Among US AdultsJAMA, 2002
- Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)JAMA, 2001
- Insulin resistance and cardiovascular diseaseJournal of Clinical Investigation, 2000
- Stable isotope turnover of apolipoproteins of high-density lipoproteins in humansCurrent Opinion in Lipidology, 2000
- Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO ConsultationDiabetic Medicine, 1998
- Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23)BMJ, 1998
- Apolipoprotein A-I and B Levels and the Risk of Ischemic Heart Disease During a Five-Year Follow-up of Men in the Que´bec Cardiovascular StudyCirculation, 1996
- Effects of Fat-Modified Diets on Cholesterol and Lipoprotein MetabolismAnnual Review of Nutrition, 1987